The basal portion (further from lumen) of an intestinal crypt. Contains multipotent stem cells. Stem cells in the crypts divide to form daughter cells. One daughter cell from each stem cell division is retained as a stem cell. The other becomes committed to differentiate along one of four pathways to become an enterocyte, enteroendocrine cell, goblet cell or Paneth cell. [ http://purl.obolibrary.org/obo/UBERON_md http://orcid.org/0000-0002-6601-2165 ]
Synonyms: basal portion of intestinal gland base of intestinal gland base part of epithelium of intestinal gland
Term information
mouse_subset, human_subset
Clearly defined prolifieration zones found in mammals. Not observed in agnathostomes, larval amphibians. Described in advanced species of fish and adult amphibians.
Term relations
- epithelium and part of some crypt of Lieberkuhn and continuous with some wall of crypt of Lieberkuhn
- epithelium
- epithelium of crypt of Lieberkuhn
- part of some crypt of Lieberkuhn
- continuous with some wall of crypt of Lieberkuhn