A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development. [ http://www.ncbi.nlm.nih.gov/pubmed/39358509 http://www.ncbi.nlm.nih.gov/pubmed/29714721 http://www.ncbi.nlm.nih.gov/pubmed/22527717 http://www.ncbi.nlm.nih.gov/pubmed/35237268 ]