All terms in GO

Label Id Description
obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding GO_0038053 [OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements.]
G protein-coupled estrogen receptor activity GO_0038054 [Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.]
nitric oxide-cGMP-mediated signaling GO_0038060 [An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.]
nitric oxide mediated signal transduction GO_0007263 [An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.]
non-canonical NF-kappaB signal transduction GO_0038061 [An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).]
dynorphin receptor activity GO_0038048 [Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.]
GO_0038049 GO_0038049
GO_0038044 GO_0038044
large latent transforming growth factor-beta complex GO_0038045 [A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.]
G protein-coupled enkephalin receptor activity GO_0038046 [Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.]
morphine receptor activity GO_0038047 [Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.]
obsolete cross-receptor activation within G-protein coupled receptor heterodimer GO_0038040 [OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter.]
cross-receptor inhibition within G protein-coupled receptor heterodimer GO_0038041 [Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.]
GO_0038042 GO_0038042
interleukin-5-mediated signaling pathway GO_0038043 [The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.]
GO_0038050 GO_0038050
obsolete MAP kinase kinase kinase activity involved in innate immune response GO_0038077 [OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response.]
obsolete MAP kinase phosphatase activity involved in regulation of innate immune response GO_0038078 [OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response.]
obsolete MAP kinase activity involved in osmosensory signaling pathway GO_0038079 [OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.]
obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion GO_0038073 [OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis.]