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nuclear pre-replicative complex
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GO_0005656 |
[A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins.] |
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pre-replicative complex
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GO_0036387 |
[A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.] |
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replication fork
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GO_0005657 |
[The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.] |
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alpha DNA polymerase:primase complex
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GO_0005658 |
[A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a small stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.] |
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GO_0005659
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GO_0005659 |
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obsolete transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
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GO_0030617 |
[OBSOLETE. A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators.] |
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obsolete transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
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GO_0030618 |
[OBSOLETE. A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.] |
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U1 snRNA binding
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GO_0030619 |
[Binding to a U1 small nuclear RNA (U1 snRNA).] |
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GO_0030610
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GO_0030610 |
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arsenate reductase activity
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GO_0030611 |
[Catalysis of the reaction: arsenite + A + H2O = arsenate + AH2 + H+.] |
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arsenate reductase (thioredoxin) activity
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GO_0030612 |
[Catalysis of the reaction: arsenate + [thioredoxin]-dithiol + H+ = arsenite + [thioredoxin]-disulfide + H2O.] |
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GO_0030615
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GO_0030615 |
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obsolete transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
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GO_0030616 |
[OBSOLETE. A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription.] |
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obsolete delta-DNA polymerase cofactor complex
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GO_0005660 |
[OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP.] |
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GO_0005661
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GO_0005661 |
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DNA replication factor A complex
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GO_0005662 |
[A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.] |
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DNA replication factor C complex
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GO_0005663 |
[A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.] |
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nuclear origin of replication recognition complex
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GO_0005664 |
[A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.] |
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RNA polymerase II, core complex
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GO_0005665 |
[RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.] |
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RNA polymerase III complex
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GO_0005666 |
[RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.] |