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Roxarsone
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DB11458 |
[Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use in pigs.] |
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Rotenone
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DB11457 |
[Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.] |
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Glucagon-like peptide II
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DB12788 |
[Glucagon-like peptide II is under investigation for the basic science of Short Bowel Syndrome.] |
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Dinoprost
|
DB12789 |
[Dinoprost has been investigated in Headache.] |
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NS-018
|
DB12784 |
[NS-018 has been used in trials studying the treatment of Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, and Post-Essential Thrombocythemia Myelofibrosis.] |
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Poloxalene
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DB11451 |
[Ethylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen and two carbon atoms).] |
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Furaprevir
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DB12785 |
[Furaprevir is under investigation in clinical trial NCT01523990 (A Study to Evaluate the Safety, Tolerability, and PK in Healthy Volunteers and HCV Genotype 1 Infected Patients).] |
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Pimobendan
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DB11450 |
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Alvircept Sudotox
|
DB12786 |
[Alvircept Sudotox has been used in trials studying the treatment of HIV Infections.] |
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Norethandrolone
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DB12787 |
[Norethandrolone is under investigation in clinical trial NCT00700544 (Treatment Outcome in Elderly Patients).] |
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Ronnel
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DB11456 |
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Quinfamide
|
DB12780 |
[Quinfamide has been used in trials studying the treatment of Amoebiasis and Helminthiasis.] |
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Robenacoxib
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DB11455 |
[Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.] |
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Balaglitazone
|
DB12781 |
[Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2.] |
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Prostalene
|
DB11454 |
[Analog of prostaglandin F2 alpha.] |
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SCH-486757
|
DB12782 |
[Sch 486757 has been used in trials studying the treatment of Cough.] |
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Benserazide
|
DB12783 |
[When levodopa is used by itself as a therapy for treating Parkinson's disease, its ubiquitous metabolism into dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. This can result in a number of side effects like nausea, vomiting, or even cardiac arrhythmias that may diminish patient adherence [F2, L2553]. A decarboxylase inhibitor like benserazide is consequently an effective compound to combine with levadopa as it is incapable of crossing the blood-brain barrier itself but acts to prevent the formation of dopamine from levadopa in extracerebral tissues - thereby acting to minimize the occurrence of extracerebral side effects [F2, L2553].
Levodopa/benserazide combination products are used commonly worldwide for the management of Parkinson's disease. In particular, although the specific levodopa/benserazide combination is formally approved for use in Canada and much of Europe, the FDA has approved another similar levodopa/dopa decarboxylase inhibitor combination in the form of levodopa and carbidopa.
Moreover, the European Medcines Agency has conferred an orphan designation upon benseraside since 2015 for its potential to be used as a therapy for beta thalassaemia as well [F3].] |
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Copper
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DB09130 |
[Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. Copper is commonly used in contraceptive intrauterine devices (IUD) [L801].] |
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Gadoteric acid
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DB09132 |
[Gadoteric acid is a macrocycle-structured gadolinium-based MRI contrast agent. It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). As a paramagnetic molecule, gadoterate develops a magnetic moment when placed in a magnetic field. This magnetic moment enhances the relaxation rates of water protons in its vicinity, leading to an increase in signal intensity (brightness) of tissues. More specifically, it reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in NMR, which is the source of its clinical utility. Increased signal brightness allows it to be used in imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'.
Gadoteric acid, as the FDA approved product Dotarem, is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.] |
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Cupric Chloride
|
DB09131 |
[Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).] |
