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Blonanserin
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DB09223 |
[Blonanserin is an atypical antipsychotic approved in Japan in January, 2008. It offers improved tolerability as it lacks side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. As a second-generation (atypical) antipsychotic, it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics.] |
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Oxybuprocaine
|
DB00892 |
[Oxybuprocaine is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.] |
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RP-5063
|
DB09226 |
[RP5063, also known as RP5000, is an investigational atypical antipsychotic which is under development by Reviva Pharmaceuticals for the treatment of schizophrenia and schizoaffective disorder. Reviva Pharmaceuticals also intends to investigate RP5063 for the treatment of bipolar disorder, major depressive disorder, psychosis/agitation associated with Alzheimer's disease, Parkinson's disease psychosis, attention deficit hyperactivity disorder (ADD/ADHD), and autism. As of May 2015, it is in phase III clinical trials for schizophrenia.] |
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Sulfapyridine
|
DB00891 |
[Antibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.] |
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Zotepine
|
DB09225 |
[Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd.[A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA. In 1993, it was classified as inactive drug substance (Status I, Type II) and in 1995 the FDA studied the manufacturing procedures of Zotepine tablets in Germany, but the status remained inactive.[L1082] When the analysis of antipsychotics was retaken in 2016 by the FDA, zotepine did not reach the threshold effect to be further studied.[L1313]. In the EMA, by 2015 it was under pharmacovigilance studies for the potential treatment of acute renal failure.[L1314]] |
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Niguldipine
|
DB09239 |
[Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.] |
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Toluene
|
DB11558 |
[Toluene is a colorless, liquid that is immiscible in water. It is a mono-substituted benzene derivative used in veterinary medicine as a treatment for various parasites in dogs and cats.] |
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Manidipine
|
DB09238 |
[Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.] |
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Detomidine
|
DB11556 |
[Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as _Dormosedan_. Currently, it is only approved by the FDA for use in horses but has been studied for use in other large animals.] |
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Tazemetostat
|
DB12887 |
[Tazemetostat has been used in trials studying the treatment of Rhabdoid Tumors, Synovial Sarcoma, Epithelioid sarcoma, INI1-negative Tumors, and Renal Medullary Carcinoma, among others.] |
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Ezutromid
|
DB12888 |
[Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne.] |
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Velneperit
|
DB12889 |
[Velneperit has been used in trials studying the treatment of Obesity.] |
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Eltoprazine
|
DB12883 |
[Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment.] |
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Trenbolone
|
DB11551 |
[Trenbolone, also known as trienolone or trienbolone, is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.] |
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Lavoltidine
|
DB12884 |
[Lavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease.] |
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CF-102
|
DB12885 |
[CF-102 has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma.] |
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GSK-1521498
|
DB12886 |
[GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.] |
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Zolazepam
|
DB11555 |
[Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.] |
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Tylvalosin
|
DB11554 |
|
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Interleukin-10
|
DB12880 |
[Interleukin-10 has been used in trials studying the prevention and treatment of Vasculitis, Pancreatitis, Bile Duct Diseases, Pancreatic Diseases, and Gallbladder Diseases, among others.] |
