|
O,O-DIETHYL HYDROGEN THIOPHOSPHATE
|
DB07674 |
|
|
Fiboflapon
|
DB06346 |
|
|
Belinostat
|
DB05015 |
[Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies for the treatment of PTCL. Intravenous administration of the agent is available as Beleodaq as monotherapy and the dosing regimen involves a 21-day cycle. It was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma.] |
|
XL999
|
DB05014 |
[XL999 has the potential to provide benefit to patients with lung cancer and acute myelogenous leukemia. XL999 is a new chemical entity that inhibits a spectrum of receptor tyrosine kinases (RTKs) with growth promoting and angiogenic properties, including FGFR 1/3, PDGFRα/β, VEGFR2/KDR, KIT, and FLT3. XL999 also inhibits FLT4 and SRC. XL999 has the potential to prevent tumor growth — both directly by a novel effect on tumor cell proliferation and indirectly through inhibition of the host angiogenic response. XL999 induces a cell-cycle block by a mechanism distinct from those previously identified and exhibits broad antitumor activity in xenograft models.
] |
|
AR-9281
|
DB06345 |
[AR-9281 inhibits soluble epoxide hydrolase.] |
|
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
|
DB07675 |
|
|
Darapladib
|
DB06311 |
|
|
Flubendazole
|
DB08974 |
[Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.] |
|
5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine
|
DB07643 |
|
|
Florantyrone
|
DB08975 |
[Florantyrone is used in the treatment of biliary dyskinesia] |
|
5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
|
DB07644 |
|
|
Motavizumab
|
DB06310 |
|
|
SEBACIC ACID
|
DB07645 |
|
|
Floctafenine
|
DB08976 |
[Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.] |
|
UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE
|
DB07646 |
|
|
Fentonium
|
DB08978 |
[Fentonium is an atropine derivative.] |
|
(2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
|
DB07647 |
|
|
(2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
|
DB07648 |
|
|
Fenspiride
|
DB08979 |
[Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.] |
|
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(benzylsulfanyl)methyl]pyrrolidin-3-ol
|
DB07649 |
|
