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temporal region
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BFO_0000008 |
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two-dimensional spatial region
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BFO_0000009 |
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thyroid disease
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EFO_1000627 |
[A disease involving the thyroid gland., A thyroid disease is a medical condition impairing the function of the thyroid. Different thyroid diseases include Hashimoto's thyroiditis, hyperthyroidism and hypothyroidism. These diseases have a large range of symptoms and affect all ages.] |
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cellular process
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GO_0009987 |
[Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.] |
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biological_process
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GO_0008150 |
[A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.] |
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brain aging
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BMONT_0000138 |
[Brain aging is a complex process that affects everything from the subcellular to the organ level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily characterized by brain volume loss, cortical thinning, white matter degradation, loss of gyrification, and ventricular enlargement. Pathophysiologically, brain aging is associated with neuron cell shrinking, dendritic degeneration, demyelination, small vessel disease, metabolic slowing, microglial activation, and the formation of white matter lesions.] |
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colorectal cancer
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DOID_9256 |
[A large intestine cancer that is located_in the colon and/or located_in the rectum.] |
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GrimAge clock
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BMONT_0000145 |
[An epigenetic clock called DNA methylation GrimAge (DNAmGrimAge) was specifically designed to connect the relationship between “grim” events such as death and biological age and its derivation was based on smoking pack-years and multiple inflammatory proteins associated with mortality.] |
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mitotic clock
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BMONT_0000146 |
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chronic kidney disease
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DOID_784 |
[A kidney failure that is characterized by the gradual loss of kidney function.] |
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decline in stem cell function
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BMONT_0000147 |
[The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases.] |
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stem cell quantity
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BMONT_0000148 |
[The decline in stem cell function is a well-established feature of the aging process and plays a crucial role in the overall degeneration of tissues and organs as we age. Stem cells are responsible for tissue regeneration, repair, and maintaining homeostasis in the body. As we age, the function of these stem cells diminishes, leading to impaired tissue repair, reduced regeneration capacity, and an increased risk of age-related diseases.] |
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hannum clock
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BMONT_0000141 |
[The Hannum Clock is one of the early and widely recognized epigenetic clocks designed to estimate biological age by analyzing DNA methylation patterns. It was developed by Dr. Gregory Hannum and his colleagues in 2013 and represents a key advancement in the field of aging research.] |
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myocardial ischemia
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MONDO_0024644 |
[A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction).] |
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vascular disease
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DOID_178 |
[A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart.] |
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horvath clock
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BMONT_0000142 |
[The Horvath Clock, developed by Dr. Steve Horvath in 2013, is a groundbreaking epigenetic clock that estimates biological age based on DNA methylation patterns. This clock is widely regarded as one of the most accurate and versatile tools for measuring biological aging across different tissues and cell types. The Horvath Clock uses the methylation levels at specific CpG sites (regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide) to estimate an individual’s biological age. Methylation at these sites tends to correlate strongly with chronological age, but it can also reveal biological age, reflecting an individual's health status and aging rate.] |
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DNAm PhenoAge
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BMONT_0000143 |
[https://pubmed.ncbi.nlm.nih.gov/31780646/, DNAm PhenoAge is an epigenetic clock that allows for an estimate of phenotypic age from a single array, obviating the need for multiple assays to measure the nine blood-based components of phenotypic age.] |
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feces
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UBERON_0001988 |
[Portion of semisolid bodily waste discharged through the anus[MW,modified].] |
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excreta
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UBERON_0000174 |
[A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.] |
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phenotypic age
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BMONT_0000144 |
[Phenotypic age refers to an individual’s biological age, which is determined by their physical characteristics and functioning rather than their chronological age] |
